anti-Polymerase (DNA Directed), gamma (POLG) Antibodies

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. Additionally we are shipping POLG Proteins (12) and POLG Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
POLG 85472 Q9QYV8
POLG 5428 P54098
POLG 18975  
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Top anti-POLG Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Polg Antibody   Titration: 1.0 ug/ml   Positive Control: Rat Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: DNA Polymerase gamma Antibody [NBP1-33633] - Paraffin-embedded Skeletal Muscle, using antibody 10 ug/ml. Western Blot: DNA Polymerase gamma Antibody [NBP1-33633] - Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Western Blot: DNA Polymerase gamma Antibody [NBP1-52300] - Analysis of anti-POLG antibody with (30 ug of whole cell lysate). A: 293T. 5% SDS PAGE. POLG antibody diluted at 1:5000. Immunocytochemistry/Immunofluorescence: DNA Polymerase gamma Antibody [NBP1-52300] - Analysis of anti-POLG antibody with methanol-fixed HeLa cell at 1:200 dilution. 0.05 mL Log in to see 10 to 13 Days
$556.31
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: MCF-7 5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded human skeletal muscle, using DNA polymerase gamma, antibody(10 μg/ml). 100 μL Log in to see 1 to 2 Days
$358.60
Details
Mouse Rabbit Un-conjugated FACS, IF, IHC (p), WB POLG Antibody (C-term)  western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the POLG antibody detected the POLG protein (arrow). POLG Antibody (C-term)  flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human laryngeal tissue labeled with Anti-DNA Polymerase gamma Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Log in to see 14 to 21 Days
$318.45
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-POLG antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μL Log in to see 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescence analysis of methanol-fixed HeLa, using DNA polymerase gamma antibody at 1:200 dilution. Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry-Paraffin: DNA Polymerase gamma Antibody [NBP2-33800] - liver cancer Immunohistochemistry-Paraffin: DNA Polymerase gamma Antibody [NBP2-33800] - Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in hematopoietic cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details

POLG Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-POLG Antibodies

  1. Human Polyclonal POLG Primary Antibody for ICC, IF - ABIN4305533 : Wu, Li, Zhang, Wu, Huang, Chen: Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine. in Mutation research 2009 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal POLG Primary Antibody for IF (p) - ABIN1696002 : Prasad, Çağlayan, Dai, Nadalutti, Zhao, Gassman, Janoshazi, Stefanick, Horton, Krasich, Longley, Copeland, Griffith, Wilson: DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria. in DNA repair 2017 (PubMed)

  3. Human Polyclonal POLG Primary Antibody for IF (p), IHC (p) - ABIN1714946 : Chen, Zhao, Cai, Sun, Hu, Huang, Kong, Kong: The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways. in Redox biology 2017 (PubMed)

  4. Cow (Bovine) Polyclonal POLG Primary Antibody for WB - ABIN2783430 : Mancini, Roncaglia, Brussino, Stevanin, Lo Buono, Krmac, Maltecca, Gazzano, Bartoletti Stella, Calvaruso, Iommarini, Cagnoli, Forlani, Le Ber, Durr, Brice, Ghigo, Casari, Porcelli, Funaro, Gasparre et al.: Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. ... in BMC medical genomics 2013 (PubMed)

More Antibodies against POLG Interaction Partners

Human Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. The POLG1 CAG repeat (show CELF3 Antibodies) length variation and the GBA (show GBA Antibodies) p.L444P variant are associated with Parkinson's disease in the Finnish population

  2. Two tag SNPs of TFAM and POLG were associated with multibacillary leprosy in Han Chinese from Southwest China.

  3. POLG phenotypes and natural history of early-onset POLG-related disorders in a large multinational pediatric cohort

  4. Together with mitochondrial dysfunction in bipolar disorder, the present results suggested deleterious POLG1 variants as a credible risk for the multifactorial disease.

  5. This study suggests that, at variance with mouse and un/de-differentiated human cells, differentiated human cells control mtDNA levels irrespective of POLG methylation.

  6. One patient presented with Leigh syndrome and had a homozygous deletion in the NDUFAF2 gene, while the second patient had a homozygous mutation in the POLG gene, [c.1399G>A; p.Ala467Thr].

  7. The rs758130 in POLG gene was significantly associated with the prognosis of patients in a dose-dependent manner. Moreover, GG genotype in rs1061316 showed significantly high mtDNA content, an indicator of better prognosis.

  8. Pol G composes the mtDNA replication machinery, this replication machinery and failure to repair these mtDNA errors results in mtDNA mutations and as a result mitochondrial dysfunction - a major driving force behind aging and age-related diseases.

  9. POLG mutations are associated with progressive external ophthalmoplegia.

  10. tudies on the impact of mitochondrial DNA variants present conflicting data but highlight POLG as a particularly interesting candidate gene for both male and female infertility.

Mouse (Murine) Polymerase (DNA Directed), gamma (POLG) interaction partners

  1. Cardiac mitochondrial polymerase gamma dysfunction alters nuclear DNA methylation (show HELLS Antibodies).

  2. Taken together, our findings may provide clues to further investigate the molecular mechanism underlying premature aging phenotype in Polg mutant mice.

  3. POLG's 3'-5' exonuclease (show EXOSC10 Antibodies) proofreading activity is required for the creation of ligatable ends during mtDNA replication.

  4. PolG mice display an enhanced reliance on glycolysis as compared to their wild-type counterparts.

  5. mitochondrial respiratory chain proteins are specifically decreased in abundance in the brains of the polg mutator mice, including several nuclear encoded mitochondrial components.

  6. in a mouse odel of diabetic retinopathy, POLG1 continued to be down-regulated, the D-loop region damaged, and the CpG islands at the regulatory region of POLG hyper-methylated even after three months of glycemic control

  7. This method gives us insights into the pausing of two pol-gamma variants: the A467T substitution that causes PEO (show C10ORF2 Antibodies) and Alpers syndrome, and the exonuclease (show EXO1 Antibodies) deficient pol-gamma (exo (show XRN1 Antibodies)(-)) in premature aging mouse models.

  8. reduced diabetic symptoms of aging Polg (D257A mutation in mitochondrial DNA polymerase gamma) Akita males results from appetite suppression triggered by decreased testosterone associated with damage to the Leydig cells of the testis

  9. Control region multimers demonstrate that polymerase-gamma 3'-5' exonuclease (show EXOSC10 Antibodies) activity is required for preserving mtDNA integrity.

  10. causative link between mtDNA mutations and ageing phenotypes, seen in Polg mutant knock-in mice

POLG Antigen Profile

Protein Summary

Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with POLG

  • polymerase (DNA) gamma, catalytic subunit L homeolog (polg.L) antibody
  • DNA polymerase gamma, catalytic subunit (Polg) antibody
  • DNA polymerase gamma, catalytic subunit (POLG) antibody
  • polymerase (DNA directed), gamma (POLG) antibody
  • polymerase (DNA directed), gamma (polg) antibody
  • polymerase (DNA directed), gamma (Polg) antibody
  • AA409516 antibody
  • MDP1 antibody
  • MIRAS antibody
  • MTDPS4A antibody
  • MTDPS4B antibody
  • PEO antibody
  • POLG antibody
  • POLG1 antibody
  • PolgA antibody
  • SANDO antibody
  • SCAE antibody

Protein level used designations for POLG

DNA polymerase gamma , DNA polymerase subunit gamma-1 , DNA-directed DNA polymerase gamma , mitochondrial DNA polymerase catalytic subunit , polG-alpha , polymerase (DNA directed), gamma , DNA polymerase subunit gamma-1-like , PolG-alpha , DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha) , Pol gamma , mitochondrial DNA polymerase gamma , mitochondrial DNA polymerase-gamma , mitochondrial polymerase gamma , polymerase, gamma

GENE ID SPECIES
397851 Xenopus laevis
85472 Rattus norvegicus
404292 Gallus gallus
467754 Pan troglodytes
488732 Canis lupus familiaris
699750 Macaca mulatta
100038061 Xenopus (Silurana) tropicalis
100053827 Equus caballus
100408039 Callithrix jacchus
5428 Homo sapiens
18975 Mus musculus
100150924 Danio rerio
100728907 Cavia porcellus
100157469 Sus scrofa
533090 Bos taurus
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