MYC
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
7-00E-10
unconjugated
Application Notes
ELISA: 1/20000-1/40000. Immunohistochemistry: 1/50-1/200. Immunoprecipitation: 1/50-1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.Synonyms: BHLHE39, Class E basic helix-loop-helix protein 39, Myc proto-oncogene protein, Transcription factor p64