PTPN11 antibody (AA 246-520) (HRP)

Catalog No. ABIN7174088

Product Details anti-PTPN11 Antibody (HRP)

Target: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Binding Specificity: AA 246-520

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN11 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Tyrosine-protein phosphatase non-receptor type 11 protein (246-520AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PTPN11

Target: PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))

Alternative Name: PTPN11 (PTPN11 Products)

Synonyms: BPTP3 antibody, CFC antibody, NS1 antibody, PTP-1D antibody, PTP2C antibody, SH-PTP2 antibody, SH-PTP3 antibody, SHP2 antibody, 2700084A17Rik antibody, AW536184 antibody, PTP1D antibody, SAP-2 antibody, SHP-2 antibody, Shp2 antibody, Syp antibody, SYP antibody, bptp3 antibody, cfc antibody, ns1 antibody, ptp-2 antibody, ptp2c antibody, ptpn11 antibody, ptpn11-a antibody, ptpn11-b antibody, shp-2 antibody, shp2 antibody, fa14b09 antibody, wu:fa14b09 antibody, wu:fi24f03 antibody, zgc:55388 antibody, zgc:63553 antibody, protein tyrosine phosphatase, non-receptor type 11 antibody, protein tyrosine phosphatase, non-receptor type 11 S homeolog antibody, protein tyrosine phosphatase, non-receptor type 11, a antibody, protein tyrosine phosphatase, non-receptor type 11, b antibody, PTPN11 antibody, Ptpn11 antibody, ptpn11.S antibody, ptpn11a antibody, ptpn11b antibody

Target Type: Viral Protein

Background:

Background: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).

Aliases: BPTP3 antibody, CFC antibody, JMML antibody, METCDS antibody, MGC14433 antibody, NS1 antibody, OTTHUMP00000166107 antibody, OTTHUMP00000166108 antibody, Protein tyrosine phosphatase 2 antibody, Protein tyrosine phosphatase 2C antibody, Protein tyrosine phosphatase non receptor type 11 antibody, Protein-tyrosine phosphatase 1D antibody, Protein-tyrosine phosphatase 2C antibody, PTN11_HUMAN antibody, PTP-1D antibody, PTP-2C antibody, PTP1D antibody, PTP2C antibody, PTPN11 antibody, SAP2 antibody, SH-PTP2 antibody, SH-PTP3 antibody, SH2 domain containing protein tyrosine phosphatase 2 antibody, SHP 2 antibody, SHP-2 antibody, Shp2 antibody, SHPTP2 antibody, SHPTP3 antibody, Syp antibody, Tyrosine-protein phosphatase non-receptor type 11 antibody

UniProt: Q06124

Pathways: JAK-STAT Signaling, RTK Signaling, TCR Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, Warburg Effect