SARS-CoV-2 / 2019-nCoV: Vaccines, Drug Discovery & Diagnostics to prevent and control Infections

Options to control or prevent emerging infections of 2019-nCoV include vaccines, monoclonal antibodies, oligonucleotide-based therapies, peptides, interferon therapies and small-molecule drugs. Among these options, vaccines against SARS-CoV-2 and repurposing existing antiviral agents which have been developed for other viruses are currently receiving the most attention. We offer a hand-selected range of products for the following categories.

Our products are not for individual resale to private persons. They are intended for use by the research community including academic, government and corporations.

SARS-CoV-2 Vaccine Development

Immunizations with SARS-CoV-2 Structural Proteins

Coronavirus structural proteins are being used to trigger an immune response in the research model being used.(1)

SARS-CoV-2 Structural Proteins

Product Cat. No. Source Application Quantity Relevance ProductGrid: uniqueid
SARS-CoV-2 Spike Subunit S2 (SARS-CoV-2 S2) (AA 697-1213) protein (His tag) ABIN6952326 Escherichia coli (E. coli) 100 μg element-ABIN6952326
SARS-CoV-2 Spike Subunit S1 (SARS-CoV-2 S1) (AA 697-1213) protein (His tag) ABIN6952319 HEK-293 Cells 200 μL element-ABIN6952319
SARS-CoV-2 Spike Subunit S1 (SARS-CoV-2 S1) (AA 319-541) protein (His tag) ABIN6952323 Escherichia coli (E. coli) 100 μg element-ABIN6952323
SARS-CoV-2 Spike Subunit S1 (SARS-CoV-2 S1) (AA 16-690) protein (His tag) ABIN6952318 HEK-293 Cells 200 μL element-ABIN6952318
SARS-CoV-2 Spike Subunit S1 (SARS-CoV-2 S1) (AA 16-690) protein (His tag) ABIN6952320 Escherichia coli (E. coli) 100 μg element-ABIN6952320
SARS-CoV-2 Spike Subunit S1 (SARS-CoV-2 S1) (AA 16-685) protein (His tag) ABIN6952427 HEK-293 Cells 100 μg element-ABIN6952427
SARS-CoV-2 Spike Protein (SARS-CoV-2 S) (AA 16-685) protein (AVI tag,Biotin,His tag) ABIN6952457 HEK-293 Cells 200 μg element-ABIN6952457
SARS-CoV-2 Spike Protein (SARS-CoV-2 S) (AA 16-1213), (Arg683Ala-Mutant), (Arg685Ala-Mutant) protein (His tag) ABIN6952426 HEK-293 Cells 100 μg element-ABIN6952426
SARS-CoV-2 S1 Subunit Protein (RBD) (SARS-CoV-2 S1 RBD) (AA 319-541) protein (AVI tag,Biotin,His tag) ABIN6952456 HEK-293 Cells 200 μg element-ABIN6952456
SARS-CoV-2 Nucleocapsid Protein (SARS-CoV-2 N) (AA 1-419) protein (His tag) ABIN6952315 HEK-293 Cells 200 μL element-ABIN6952315
SARS-CoV-2 Nucleocapsid Protein (SARS-CoV-2 N) (AA 1-419) protein (His tag) ABIN6952312 Escherichia coli (E. coli) 100 μg element-ABIN6952312
SARS-CoV-2 Nucleocapsid Protein (SARS-CoV-2 N) (AA 1-419) protein (His tag) ABIN6952454 HEK-293 Cells 100 μg element-ABIN6952454

SARS-CoV Structural Proteins

Product Cat. No. Source Application Quantity Relevance ProductGrid: uniqueid
SARS-Coronavirus Spike Protein (SARS-CoV S) (N-Term) protein ABIN573707 Escherichia coli (E. coli) EIA, WB 1 mg element-ABIN573707
SARS-Coronavirus Spike Protein (SARS-CoV S) (Middle Region) protein ABIN573704 Escherichia coli (E. coli) EIA, WB 1 mg element-ABIN573704
SARS-Coronavirus Spike Protein (SARS-CoV S) (C-Term) protein ABIN573706 Escherichia coli (E. coli) EIA, WB 1 mg element-ABIN573706
SARS-Coronavirus Spike Protein (SARS-CoV S) (AA 1-1190) protein (His tag) ABIN1605601 HEK-293 Cells WB, ELISA, Imm 100 μg element-ABIN1605601
SARS-Coronavirus Nucleocapsid Protein (SARS-CoV N) (AA 1-422) protein (His tag) ABIN2650338 Baculovirus infected Insect Cells 100 μg element-ABIN2650338
SARS-Coronavirus Membrane Protein (SARS-CoV M) protein ABIN624168 Escherichia coli (E. coli) 1 mg element-ABIN624168
SARS-Coronavirus Envelope Protein (SARS-CoV E) protein ABIN573717 Escherichia coli (E. coli) EIA, WB 1 mg element-ABIN573717
SARS-Coronavirus Envelope Protein (SARS-CoV E) (N-Term) protein ABIN621876 Escherichia coli (E. coli) 1 mg element-ABIN621876

Immunogen Identification with SARS-CoV-2 Proteome Microarray

The SARS-CoV-2 Proteome Microarray can be used to screen sera (derived from patients, animals) against 4,883 individual peptides spanning the entire viral proteome. Thereby, the SARS-CoV-2 Proteome Microarray can detect IgG and IgM antibody responses on the epitope level in patient sera for vaccine development. Click on the link below to find more detailed information about the proteome microarray.

2019-nCoV (Coronavirus) Proteome Microarray

Testing Immune Response with SARS-CoV-2 IgG & IgM Antibody Detection Kits

These easy-to-use rapid tests (for research only) can be used to detect IgG or IgM antibodies to Human SARS-CoV-2 in serum, plasma, and peripheral blood.

Product Cat. No. Quantity Relevance ProductGrid: uniqueid
Human Anti-SARS-CoV-2 (Covid-19) IgM Rapid Test ABIN6952534 25 tests element-ABIN6952534
Human Anti-SARS-CoV-2 (Covid-19) IgG / IgM Rapid Test ABIN6952533 25 tests element-ABIN6952533

SARS-CoV-2 Drug Discovery

ACE2 Inhibition/Knock-Down Control with ACE2 Antibodies

Repurposing existing drugs to fight SARS-CoV-2 is viewed as the fastest way to provide a cure for COVID-19. When studying the impact of existing drugs on SARS-CoV-2, ACE2 plays a key role as it has been identified as the receptor through which SARS-CoV-2 enters the host cells.(2) Please find below a selection of reliable monoclonal and polyclonal ACE2 antibodies:

Product Cat. No. Reactivity Clonality Source Application Quantity Relevance ProductGrid: uniqueid
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) antibody ABIN6925724 Human Polyclonal Rabbit 100 μL element-ABIN6925724
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) antibody (Biotin) ABIN1169450 Human Monoclonal Mouse ELISA, FACS, WB 50 μg element-ABIN1169450
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) antibody ABIN1169446 Human Polyclonal Rabbit ELISA, WB 100 μg element-ABIN1169446
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) antibody ABIN1169449 Human Monoclonal Mouse ELISA, FACS, WB 100 μg element-ABIN1169449
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) (N-Term) antibody ABIN2855030 Human, Mouse (Murine) Polyclonal Rabbit IHC (p), WB 100 μL element-ABIN2855030
anti-Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) (AA 599-649) antibody ABIN730798 Human, Mouse (Murine), Pig (Porcine), Rat (Rattus) Polyclonal Rabbit WB, IHC (p), IF (p) 100 μL element-ABIN730798

For quick and easy detection of ACE2 we offer a range of validated ACE2 ELISA kits with Pubmed references. For more details click on the links:

Product Reactivity Detection Method Cat. No. Quantity Relevance ProductGrid: uniqueid
SensoLyte® 390 ACE2 Activity Assay Kit Fluorometric ABIN1882389 1 kit element-ABIN1882389
Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) ELISA Kit Human Colorimetric
(Pre-coated)
ABIN415147 96 tests element-ABIN415147
Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) ELISA Kit Rat (Rattus) Colorimetric
(Pre-coated)
ABIN431519 96 tests element-ABIN431519
Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) ELISA Kit Mouse (Murine) Colorimetric
(Pre-coated)
ABIN1889360 96 tests element-ABIN1889360
Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) ELISA Kit Human Colorimetric
(Pre-coated)
ABIN1672892 96 tests element-ABIN1672892

SARS-CoV-2 Impact Assement with Cell Viability Assays

When studying the impact of drugs on the proliferation of SARS-CoV-2 monitoring the condition of the research model or its cells is of interest as well. Cell Viability Assays may be used for this purpose.

Product Cat. No. Application Quantity Relevance ProductGrid: uniqueid
SensoLyte® Calcein Cell Viability Assay Kit ABIN1882422 EAA 1 kit element-ABIN1882422
VisionBlue™ Quick Cell Viability Fluorometric Assay Kit ABIN411746 CVA, D 2500 tests element-ABIN411746
ApoSENSOR™ ATP Cell Viability Bioluminescence Assay Kit ABIN411718 CVA, D 1000 tests element-ABIN411718
Cell Viability Assay Kits ABIN1000238 CA 5000 tests element-ABIN1000238

Antibodies against SARS-CoV-2 Spike Proteins

The S protein / spike protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV.(3)

Product Cat. No. Reactivity Clonality Source Application Quantity Relevance ProductGrid: uniqueid
anti-SARS-CoV-2 Spike Protein (SARS-CoV-2 S) (C-Term) antibody ABIN1030641 Coronavirus (2019-nCoV), SARS Coronavirus (SARS-CoV) Polyclonal Rabbit ELISA 0.1 mg element-ABIN1030641
anti-SARS-Coronavirus Spike Protein (SARS-CoV S) antibody ABIN2452119 SARS Coronavirus (SARS-CoV) Monoclonal Mouse WB, IF, IC, ELISA 50 μg element-ABIN2452119
anti-SARS-Coronavirus Spike Protein (SARS-CoV S) (N-Term) antibody ABIN1031553 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit ELISA 0.1 mg element-ABIN1031553
anti-SARS-Coronavirus Spike Protein (SARS-CoV S) (Intermediate Domain 3) antibody ABIN1031207 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit ELISA 0.1 mg element-ABIN1031207
anti-SARS-Coronavirus Spike Protein (SARS-CoV S) (Intermediate Domain 2) antibody ABIN1031201 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit ELISA 0.1 mg element-ABIN1031201
anti-SARS-Coronavirus Spike Protein (SARS-CoV S) (Intermediate Domain 1) antibody ABIN1031189 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit ELISA 0.1 mg element-ABIN1031189

Antibodies against SARS-CoV-2 Non-Structural Proteins

Many of the non-structural proteins perform essential functions in viral RNA replication and transcription.(4) The NSPs NSP3, NSP5, NSP12 and NSP13 provide additional points of attack when it comes to fighting SARS-CoV-2 through drugs.

Product Cat. No. Reactivity Clonality Source Application Quantity Relevance ProductGrid: uniqueid
anti-SARS-Coronavirus RNA-dependent RNA Polymerase (SARS-CoV RdRP) antibody ABIN1605597 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit WB 200 μg element-ABIN1605597
anti-SARS-Coronavirus RNA-dependent RNA Polymerase (SARS-CoV RdRP) (C-Term) antibody ABIN1887461 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit ELISA 100 μL element-ABIN1887461
anti-SARS-Coronavirus RNA-dependent RNA Polymerase (SARS-CoV RdRP) (N-Term) antibody ABIN1888223 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit ELISA 100 μL element-ABIN1888223
anti-SARS-Coronavirus Nonstructural Protein 13 (SARS-CoV NSP13) (C-Term) antibody ABIN233793 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit WB, IEM, FM 100 μL element-ABIN233793
anti-SARS-Coronavirus 3CL Protease antibody ABIN129545 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit WB, ELISA 500 μg element-ABIN129545
anti-SARS-Coronavirus Nonstructural Protein 3 (SARS-CoV NSP3) antibody ABIN233791 SARS Coronavirus (SARS-CoV) Polyclonal Rabbit WB, IP, IEM, FM 100 μL element-ABIN233791

SARS-CoV-2 Diagnostics

Detecting SARS-CoV-2 infection fast and reliably is a key for containing the virus. The PhoenixDx® 2019-nCoV RNA Detection Kit can be used for qualitative RT-PCR-based detection of SARS-CoV-2. The easy-to-use rapid tests can be used for qualitative detection of SARS-CoV-2 IgG antibodies and SARS-CoV-2 IgM antibodies to the SARS-CoV-2 N protein in human serum, plasma, and whole blood. For more details click on the links below.

PhoenixDx® 2019-nCoV RNA Detection Kit
Novel Coronavirus (SARS-CoV-2) IgM Antibody Detection Kit (Colloidal Gold Method)
Novel Coronavirus (SARS-CoV-2) IgG Antibody Detection Kit (Colloidal Gold Method)

References

(1) Yong CY, Ong HK, Yeap SK, Ho KL, Tan WS. Recent Advances in the Vaccine Development Against Middle East Respiratory Syndrome-Coronavirus. Front Microbiol. 2019 Aug 2;10:1781. doi: 10.3389/fmicb.2019.01781. PMID: 31428074; PMCID: PMC6688523.

(2) Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 Mar 4. pii: S0092-8674(20)30229-4. doi: 10.1016/j.cell.2020.02.052

(3) Du L, He Y, Zhou Y, Liu S, Zheng BJ, Jiang S. The spike protein of SARS-CoV--a target for vaccine and therapeutic development. Nat Rev Microbiol. 2009 Mar;7(3):226-36. doi: 10.1038/nrmicro2090. Epub 2009 Feb 9. PMID: 19198616; PMCID: PMC2750777.

(4) Narayanan K, Ramirez SI, Lokugamage KG, Makino S. Coronavirus nonstructural protein 1: Common and distinct functions in the regulation of host and viral gene expression. Virus Res. 2015 Apr 16;202:89-100. doi: 10.1016/j.virusres.2014.11.019. Epub 2014 Nov 26. PMID: 25432065; PMCID: PMC4444399.