Alzheimer’s disease

Alzheimer's disease is the most common form of dementia. About 50 million people worldwide suffer from Alzheimer's disease(1). A further increase in the number of cases is expected by 2050, partly due to the fundamental rise in life expectancy. The clinical picture is characterised by a progressive loss of cognitive abilities. The neurological hallmarks are the presence of neuritic plaques and neurofibrillary tangles of proteins in brain tissue. Ultimately, the disease leads to death.

Here you will find a list of important antibodies, reagents, kits, and other tools you need for your research in the field of neurodegenerative diseases and especially Alzheimer's, as well as some more additional resources on the topic.

Important targets related to Alzheimer's Disease

The following targets are directly related to research on Alzheimer's disease. Search Antibodies, Kits, Reagents and other products.

Amyloid beta and Tau Protein

Amyloid beta and tau protein are two of the major players in Alzheimer's Disease research. Below you will find a handpicked selection of antibodies with human and mouse reactivity. Click on a link to get more details.

Amyloid beta Antibodies: Reactivity in Human and Mouse

Product Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-beta Amyloid antibody (Amyloid beta) (AA 1-16) Human, Mouse (Murine) Monoclonal IHC (p), WB ABIN1105360 0.1 mg element-ABIN1105360
anti-beta Amyloid antibody (Amyloid beta) Human Monoclonal IHC, ELISA ABIN459388 50 μg element-ABIN459388
anti-beta Amyloid antibody (Amyloid beta) (C-Term) Human, Mouse (Murine), Rat (Rattus) Monoclonal ELISA, IF, WB ABIN5508784 100 μg element-ABIN5508784
anti-beta Amyloid antibody (Amyloid beta) (N-Term) Human, Mouse (Murine) Polyclonal IHC, ELISA, WB ABIN95037 100 μg element-ABIN95037

See all Amyloid beta Antibodies

Tau Protein Antibodies: Reactivity in Human and Mouse

Product Reactivity Clonality Application Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-tau antibody (tau Protein) (AA 12-24) Human, Mouse (Murine), Rat (Rattus) Monoclonal IF, IHC, WB ABIN2443721 100 μg element-ABIN2443721
anti-tau antibody (tau Protein) (AA 3-214) Human, Rat (Rattus), Mouse (Murine) Monoclonal ICC, IP, IHC, WB ABIN1742567 100 μg element-ABIN1742567
anti-tau antibody (tau Protein) (AA 361-410) Human, Mouse (Murine), Rat (Rattus) Polyclonal WB ABIN6711926 100 μL element-ABIN6711926

See all Tau Protein Antibodies

Beta- / Gamma-Secretase Kits

Generation of Amyloid peptide (Abeta) is at the beginning of a cascade that leads to Alzheimer's disease. Currenty, the mechanisms of Abeta generation and Abeta prevention are subject of intensive research. Amyloid precursor protein (APP), as well as beta- and gamma-secretases are the principal players involved in Abeta production, while alpha-secretase cleavage on APP prevents Abeta deposition. Inhibitors or modulators that target beta- and gamma-secretases as well as alpha-secretase activators are promising candidates for treatment of Alzheimer's disease.(3) We currently offer three kits for secretase detection.

Product Reactivity Detection Method Cat. No. Quantity Relevance ProductGrid: uniqueid
Beta-Secretase Activity Fluorometric Assay Kit Mammalian Fluorometric ABIN411640 100 tests element-ABIN411640
gamma Secretase ELISA Kit Human Colorimetric
(Pre-coated)
ABIN577496 96 tests element-ABIN577496
gamma Secretase ELISA Kit Mouse (Murine) Colorimetric
(Pre-coated)
ABIN367383 96 tests element-ABIN367383

Tools for Tau Protein Phosphorylation

Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several neurodegenerative tauopathies including Alzheimer’s disease (AD) and some frontotemporal dementias. Increasing evidence suggests that the presence of these end-stage neurofibrillary lesions do not cause neuronal loss, but rather that alterations to soluble tau proteins induce neurodegeneration.(2)

Product Reactivity Epitope Cat. No. Quantity Relevance ProductGrid: uniqueid
anti-tau antibody (tau Protein) (pSer199) Human pSer199 ABIN1573962 40 μg element-ABIN1573962
anti-tau antibody (tau Protein) (pSer202) Human pSer202 ABIN1883485 50 μg element-ABIN1883485
anti-tau antibody (tau Protein) (pSer356) Human, Mouse (Murine), Rat (Rattus) pSer356 ABIN6714089 100 μL element-ABIN6714089
anti-tau antibody (tau Protein) (pThr181) Human, Mouse (Murine), Rat (Rattus) pThr181 ABIN362072 100 μL element-ABIN362072
anti-tau antibody (tau Protein) (pThr231) Human, Mouse (Murine), Rat (Rattus) pThr231 ABIN6714134 100 μL element-ABIN6714134

See all Tau Protein Antibodies

Lysates for AD Research

We offer a variety of lysates for use in Western Blotting for Alzheimer's Disease research: See all products

References

(1) Alzheimer’s Research UK. Dementia Statistics Hub - Global Prevalence. Internet: www.dementiastatistics.org/statistics/global-prevalence/

(2) Noble W, Hanger DP, Miller CC, Lovestone S. The importance of tau phosphorylation for neurodegenerative diseases. Front Neurol. 2013 Jul 1;4:83. doi: 10.3389/fneur.2013.00083. PMID: 23847585; PMCID: PMC3696910.

(3) Epis, Marcello, Gardoni, Di Luca. Alpha, beta-and gamma-secretases in alzheimer's disease, Frontiers in Bioscience S4, 1126-1150 , January 1, 2012