Browse our anti-Integrin beta 2 (ITGB2) Antibodies

Full name:: anti-Integrin beta 2 Antibodies (ITGB2)

On www.antibodies-online.com are 682 Integrin beta 2 (ITGB2) Antibodies from 31 different suppliers available. Additionally we are shipping Integrin beta 2 Proteins (17) and Integrin beta 2 Kits (15) and many more products for this protein. A total of 721 Integrin beta 2 products are currently listed.

Synonyms:: 2E6, AI528527, Cd18, itgb2, itgb2-a, itgb2-b, LAD, LCAMB, LFA-1, Lfa1, MAC-1, MF17, MFI7

list all antibodies	Gene Name	GeneID	UniProt
	ITGB2	3689	P05107
	ITGB2	16414	P11835
	ITGB2	309684
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Most Popular Reactivities for anti-Integrin beta 2 (ITGB2) Antibodies

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anti-Human Integrin beta 2 Antibodies:

anti-Mouse (Murine) Integrin beta 2 Antibodies:

anti-Rat (Rattus) Integrin beta 2 Antibodies:

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Top referenced anti-Integrin beta 2 Antibodies

Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN457404 : Abraham, Miller: Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. in Journal of immunology (Baltimore, Md. : 1950) 2001 (PubMed)
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Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN457348 : Avni, Pur, Yefenof, Baniyash: Complement receptor 3 of macrophages is associated with galectin-1-like protein. in Journal of immunology (Baltimore, Md. : 1950) 1998 (PubMed)
Show all 9 Pubmed References
Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN457430 : Sakurai, Taguchi, Anand, Ambati, Gragoudas, Miller, Adamis, Ambati: Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization. in Investigative ophthalmology & visual science 2003 (PubMed)
Show all 8 Pubmed References
Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for BR, IHC (f) - ABIN2689033 : Driessens, van Hulten, Zuurbier, La Rivière, Roos: Inhibition and stimulation of LFA-1 and Mac-1 functions by antibodies against murine CD18. Evidence that the LFA-1 binding sites for ICAM-1, -2, and -3 are distinct. in Journal of leukocyte biology 1997 (PubMed)
Show all 7 Pubmed References
Human Polyclonal Integrin beta 2 Primary Antibody for BR, FACS - ABIN5012937 : van Grevenstein, Hofland, van Rossen, van Koetsveld, Jeekel, van Eijck: Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. in Digestive diseases and sciences 2007 (PubMed)
Show all 7 Pubmed References
Mouse (Murine) Monoclonal Integrin beta 2 Primary Antibody for BR, Func - ABIN1176975 : Isobe, Yagita, Okumura, Ihara: Specific acceptance of cardiac allograft after treatment with antibodies to ICAM-1 and LFA-1. in Science (New York, N.Y.) 1992 (PubMed)
Show all 6 Pubmed References
Human Monoclonal Integrin beta 2 Primary Antibody for WB - ABIN1882257 : Chen, Xie, Nishida, Li, Walz, Springer: Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
Show all 5 Pubmed References
Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN94005 : Nakayama, Yoshizaki, Prinetti, Sonnino, Mauri, Takamori, Ogawa, Iwabuchi: Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms. in Journal of leukocyte biology 2008 (PubMed)
Show all 19 Pubmed References
Human Monoclonal Integrin beta 2 Primary Antibody for Func, IHC (f) - ABIN2749019 : Dassanayake, Maheswaran, Srikumaran: Monomeric expression of bovine beta2-integrin subunits reveals their role in Mannheimia haemolytica leukotoxin-induced biological effects. in Infection and immunity 2007 (PubMed)
Show all 12 Pubmed References
Human Monoclonal Integrin beta 2 Primary Antibody for FACS, Func - ABIN192094 : Cera, Fabbri, Molendini, Corada, Orsenigo, Rehberg, Reichel, Krombach, Pardi, Dejana: JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling. in Journal of cell science 2009 (PubMed)
Show all 20 Pubmed References

More Antibodies against Integrin beta 2 Interaction Partners

Human Integrin beta 2 (ITGB2) interaction partners

LncRNA ITGB2-AS1 (show PTGDR Antibodies) could promote the migration and invasion of breast cancer cells by up-regulating ITGB2.
Data show that integrin alphaLbeta2 (LFA-1) is oriented relative to actin retrograde flow.
Overexpression of ITGB2 was not correlated with ITGB2 promoter hypomethylation in systemic sclerosis.
actin engagement produces tension within the beta2 subunit to induce and stabilize an active integrin conformational state and that this requires intact talin and kindlin motifs.
on tumour-infiltrating T-lymphocytes, galectin prevents the formation of a functional secretory synapse by preventing optimal LFA-1 (show ITGAL Antibodies) triggering
exploration of the underlying mechanism demonstrated that ICAM3 (show ICAM3 Antibodies) not only binds to LFA-1 (show ITGAL Antibodies) with its extracellular domain and structure protein ERM (show ETV5 Antibodies) but also to lamellipodia with its intracellular domain which causes a tension that pulls cells apart (metastasis).
vesicle-associated RhoB is a regulator of the Rab11 (show RAB11A Antibodies)-mediated recycling of LFA-1 (show ITGAL Antibodies) to the cell surface, an event that is necessary for T lymphocyte motility.
The ITGB2 variant rs2230531 was examined in an independent cohort of Tasmanian patients with hematologic malignancies (HM) to see if its presence correlated with chronic lymphocytic leukemia. The variant was found in several lymphoid and myeloid HMs (show CTSC Antibodies), so if contributes to the risk of HM, it does so broadly across HM subtypes in this population.
Data suggest that the residue volume at phenylalanine (Phe) in alpha1-helix is critical for alpha(L)/beta(2) integrin (CD49a (show ITGA1 Antibodies)/CD18) activation and binding with soluble/immobilized ICAM1 (show ICAM1 Antibodies) (intercellular cell adhesion molecule 1 (show CADM1 Antibodies)).
an integrated strategy of whole genome and transcriptome analysis enabled identification of LB-ITGB2-1 as HLA-B*15:01-restricted MiHAs encoded by an alternative transcript. The alternative ITGB2 transcript was shown to be expressed in leukemic cells of different origins.

Mouse (Murine) Integrin beta 2 (ITGB2) interaction partners

CD18(-/-) leukocytes extravasated later than WT leukocytes. However, once extravasated, CD18(-/-) leukocytes transmigrated more rapidly than their WT counterparts. These results suggest that, although CD18 facilitates efficient extravasation, outside of the vessel CD18 interaction with the extracellular matrix, it reduced transmigration velocity.
A modulatory role for the tumor beta2 subunit of the LFA-1 (show ITGAL Antibodies) integrin in the metastatic progression of colorectal cancer to the liver by impaired activation of liver endothelium.
Data show CD18 is selectively required for T helper 2, but not T helper 1, homing and has a minimal influence on T-effector development.
Adhesive properties of the leukocyte integrin Mac-1 (show ITGAM Antibodies) are not required for macrophage accumulation in adipose tissue. Instead, Mac-1 (show ITGAM Antibodies) modulates inflammatory gene expression in macrophages.
in T cells, PI3Kdelta attenuates the activation of Rac1, but sustains the activation of Rap1.
An intracellular pool of LFA-1 (show ITGAL Antibodies) in naive CD8 (show CD8A Antibodies)(+) T cells plays a key role in T cell activation and differentiation.
Extracellular ISG15 (show ISG15 Antibodies) signals cytokine secretion through the LFA-1 (show ITGAL Antibodies) integrin receptor (CD11a (show ITGAL Antibodies)/CD18) in natural killer cells.
CD18 deficiency curbs methionine-choline-deficient-mediated liver injury by limiting the activation of innate immune cells in the liver without compromising intrahepatic cytokine activation
results identify a role for Caveolin (Cav (show CA5A Antibodies))1in membrane organization and beta2 integrin Lfa1 (show ITGAL Antibodies) function in primary CD8 (show CD8A Antibodies) T cells.
Coro1A (show CORO1A Antibodies) represents an important novel player in integrin biology, with key functions in polymorphonuclear neutrophils trafficking during innate immunity.

Cow (Bovine) Integrin beta 2 (ITGB2) interaction partners

Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency.
intramammarily administered lipopolysaccharides seem to play an important role in modulating L-selectin (show SELL Antibodies) and beta2 integrin expression on circulating bovine polymorphonuclear leukocytes
A delay in apoptosis was demonstrated in CD18-deficient bovine neutrophils and this appeared to be closely associated with lowered signalling via [Ca2 (show CA2 Antibodies)+]i, diminished annexin V (show ANXA5 Antibodies) expression on the cell surface, and decreased caspase 3 (show CASP3 Antibodies) activity in lysates
The I-EGF (show EGF Antibodies)-3 domain of bovine CD18 (amino acid residues 541-581) is critical for conferring species-specific susceptibility to Mannheimia haemolytica leukotoxin.
These results clearly indicate that the bovine CD18 subunit of beta(2)-integrins is the functional receptor for M. haemolytica Lkt.[ruminant-specific leukotoxin]
study provides evidence that the expression of CD18 was downregulated by the plasma glycoforms of alpha-1 acid glycoprotein (show ORM1 Antibodies) and inhibited the chemotaxis of monocytes
Loss of CD18 is associated with bovine leukocyte adhesion deficiency.
Intact signal peptide of CD18, the beta-subunit (show POLG Antibodies) of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin.

Pig (Porcine) Integrin beta 2 (ITGB2) interaction partners

CR3 (show ITGAM Antibodies) plays a cardinal (show CARD8 Antibodies) role in beta-glucan signalling in porcine neutrophils, while macrophages use a more diverse receptor array to detect and respond towards beta-glucans.
The expression of zona pellucida glycoprotein 3 (show ZP3 Antibodies) and integrin beta-2 in oocytes after brilliant cresyl blue staining is reported.
early CD18 downregulation is profitable for the host in a situation with an intense LPS (show IRF6 Antibodies) stimulus
It is concluded that porcine CD18 is necessary to mediate A. pleuropneumoniae ApxIIIA toxin-induced leukolysis.

Goat Integrin beta 2 (ITGB2) interaction partners

Integrin CD11c (show ITGAX Antibodies)/CD18 alpha-chain (show FCGRT Antibodies) phosphorylation is functionally important.

Integrin beta 2 (ITGB2) Antigen Profile

Antigen Summary

The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

Alternative names and synonyms associated with Integrin beta 2 (ITGB2)

integrin subunit beta 2 (ITGB2) antibody
integrin beta 2 (Itgb2) antibody
integrin subunit beta 2 (Itgb2) antibody
integrin subunit beta 2 S homeolog (itgb2.S) antibody

2E6 antibody
AI528527 antibody
Cd18 antibody
itgb2 antibody
itgb2-a antibody
itgb2-b antibody
LAD antibody
LCAMB antibody
LFA-1 antibody
Lfa1 antibody
MAC-1 antibody
MF17 antibody
MFI7 antibody

Protein level used designations for anti-Integrin beta 2 (ITGB2) Antibodies

, , , , , , , , , , , , , , , , , , , , , , , , , , , cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor) cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta complement receptor C3 beta-subunit complement receptor C3 subunit beta integrin beta chain, beta 2 integrin beta-2 leukocyte cell adhesion molecule CD18 leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C Mac-1 beta lymphocyte function associated antigen 1 macrophage antigen-1 beta CD18 subunit Leu-CAM receptor integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2) integrin beta 2 subunit CD18 leukocyte adhesion molecule antigen CD18 integrin beta-2 chain integrin beta 2 integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1 integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) macrophage antigen 1 (mac-1) beta subunit) Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta Complement receptor C3 subunit beta Integrin beta-2 integrin beta-2 subunit integrin subunit beta 2 S homeolog integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

GENE ID	SPECIES
3689	Homo sapiens
16414	Mus musculus
281877	Bos taurus
396181	Gallus gallus
396943	Sus scrofa
458607	Pan troglodytes
494433	Ovis aries
710577	Macaca mulatta
309684	Rattus norvegicus
100861185	Capra hircus
379708	Xenopus laevis

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