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SARS-CoV-2 Spike (P.1 - gamma) protein (rho-1D4 tag) Protein

Origin: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Gamma Host: HEK-293 Cells Recombinant > 98 % as determined by SDS-PAGE
Pubmed (1 reference)
Catalog No. ABIN6964443
$948.20
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  • Key Features
    • Recombinant trimeric S protein of the SARS-CoV-2 variant of concern P.1.
    • Contains L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, and V1176F mutations characteristic for the SARS-CoV-2 gamma variant (P.1).
    Target See all SARS-CoV-2 Spike Proteins
    SARS-CoV-2 Spike
    Protein Type
    Recombinant
    Protein Characteristics
    P.1 - gamma
    Origin
    • 140
    • 23
    • 8
    • 8
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Gamma
    Source
    • 134
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This SARS-CoV-2 Spike protein is labelled with rho-1D4 tag.
    Purpose
    This is the spike protein of the mutant strain P.1, also commonly known as the "Brazil mutant".
    Specificity
    Mutation that differ from canonical sequence of SPIKE protein: L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, H655Y, T1027I, V1176F
    Characteristics
    "SARS CoV-2 full-length Spike P.1 Mutation"
    All viruses undergo fast mutations and adept quickly to the countermeasures that the immune systems creates against them. SARS-CoV-2 of the COVID-19 pandemic is no exception here. During the pandemic multiple mutant strains arose. To help the science combat these mutants we offer the SPIKE protein of these mutants in full-length and active in its native trimeric form, stabilized with the LMNG detergent.
    Purification
    affinity chromatography
    Purity
    > 98 % as determined by SDS-PAGE
  • Comment

    Further modifications:
    - furin cleavage site "682-RRAR|SV-687" mutated to "682-GSAG|PP-687"
    - C-terminal Rho1D4 tag fused with spacer "GSSG" to protein sequence
    Size: 1286 amino acids (including Rho1D4 tag and linker)

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    20 mM Hepes pH 7.5, 150 mM NaCl, 0.001 % LMNG
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Avoid freeze-thaw cycles
  • Bhalla, Payam, Morelli, Sharma, Johnson, Thomson, Jolly, Canfarotta: "Nanoplasmonic biosensor for rapid detection of multiple viral variants in human serum." in: Sensors and actuators. B, Chemical, Vol. 365, pp. 131906, (2022) (PubMed).

  • Target
    SARS-CoV-2 Spike
    Alternative Name
    SARS2 Spike glycoprotein (SARS-CoV-2 Spike Products)
    Synonyms
    E2, E2 glycoprotein precursor, Surface Glycoprotein, S
    Target Type
    Viral Protein
    Molecular Weight
    142114 Da
    UniProt
    P0DTC2
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