SARS-CoV-2 Spike Protein (B.1.351 - beta, RBD) (Fc Tag)
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- Target See all SARS-CoV-2 Spike Proteins
- SARS-CoV-2 Spike
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- B.1.351 - beta, RBD
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Origin
- SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Beta
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SARS-CoV-2 Spike protein is labelled with Fc Tag.
- Purpose
- SARS-CoV-2 S protein RBD (K417N, E484K, N501Y), Fc Tag (MALS verified)
- Sequence
- AA 319-537
- Characteristics
- SARS-CoV-2 S protein RBD (K417N,E484K,N501Y), Fc Tag is expressed from human 293 cells (HEK293). It contains AA Arg 319 - Lys 537 (Accession # QHD43416.1 (K417N, E484K, N501Y). The K417N, E484K, N501Y mutations were identified in the SARS-CoV-2 variant (known as B.1.351 or 20C/501Y.V2) which emerged in South Africa.
- Purity
- >95 % as determined by SDS-PAGE.
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product SARS-CoV-2 Spike Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
- Storage
- -20 °C
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- Target
- SARS-CoV-2 Spike
- Alternative Name
- SARS-CoV-2 S protein (SARS-CoV-2 Spike Products)
- Synonyms
- E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein
- Target Type
- Viral Protein
- Background
- It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
- Molecular Weight
- 51.1 kDa
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