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Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

The host protein has now been identified as a -dependent factor expressed inside abscesses by scientists from the Vanderbilt University (USA). derived from inhibited growth of by chelation of the nutrients Mn2+ and Zn2+. This reaction reprograms the bacterial trancriptome.

Abcesses are a frequent consequence of bacterial infection and the main site of interaction between invading bacteria and the host's innate immune system. The scientists analysed abscesses of mice lacking . They turned out to be enriched in metal while the proliferation of was increased in this metal-rich environment. Metal chelation therefore proofs to be a successful strategy to inhibit microbial growth inside abscessed tissue.

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