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Phenotypic correction of murine hemophilia A using an stem cell-based therapy

Scientists of the Nevada Cancer Institute in Las Vegas (USA) injected and endothelial progenitor cells, both derived from induced pluripotent stem cells, into the liver of suffering from hemophilia A. Note: This antibody has been cited in this publication: anti-Factor VIII (F8) antibody (ABIN99037)

Hemophilia A is caused by mutations within the gene encoding . The transplated survived longer than 3 month despite several times of induced bleeding. levels rose upt to 12% the wild type amount, correcting the hemophilia phenotype.

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