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Research areas:

Regulation of Replication Fork Progression Through Histone Supply and Demand

seems to be a provider of fine-tuned progression of the replication fork during DNA replication and histone supply and demand. The chaperone is a histone acceptor and donor and handles parental and new histones at the replication fork through an -(-)-- intermediate, state Anja Grot and her team from the Institute Curie in France.

Histone dynamics and their coordination in concert with fork progression to maintain chromosome stability have been undiscovered so far. Now the team from France and Denmark describes a complex, connecting the human chaperone and replicative helicase - via a - bridge.

The scientists depleted and observed impeded DNA unwinding at the replication sites. Overproduction of new -, which impair function, led to similar effects.

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