You are viewing an incomplete version of our website. Please click to reload the website as full version.

CLOCK-mediated acetylation of BMAL1 controls circadian function

, a protein that regulates circadian rhythm, also acetylates its partner protein, on a unique, highly conserved Lys 537 residue, as a recent study by Jun Hirayama from the University of California (USA) shows.

, a protein that regulates circadian rhythm, also acetylates its partner protein, on a unique, highly conserved Lys 537 residue, as a recent study by Jun Hirayama from the University of California (USA) shows.

The - complex is responsible for activating -controlled genes, like (). The gene products directly repress -.

The scientists discovered that undergoes rhythmic acetylation in murine liver tissue. The timing was observed to parallel the circadian transcriptional downregulation of -controlled genes. The acetylation supports transcriptional repression by facilitating the recruitment of to - complexes.

Ectopic expression of mutated (K537R-mutation) cannot rescue circadian rhythmicity in vitro. The circadian machinery therefore requires the enzymatic interaction of two core components.

Related antibodies on antibodies-online.com: