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Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia

A research team from the University of Oxford (UK) identified a cell compartment in leukemic children that can propagate leukemia when transplanted in mice. The team analysed the clonal evolution of a form of childhood precursor- acute lymphoblastic leukaemia.

The disease is defined by a chromosomal translocation, leading to the production of a - fusion gene. The - fusion probably functions as a first-hit mutation and provides the preleukemic cell with modified self-renewal and survival properties.

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