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Plexin-B1 mutations in prostate cancer

Plexin B1 and the pathways influence the development of prostate in two different ways. Either the elevated expression of Plexin B1 in the majority of primary tumours is crucial or the numerous somatic missense mutations that were detected in the cytoplasmic domain of the Plexin-B1 gene by Oscar Gee-Wan Wong and his team from the University College London (UK) are relevant.

The mutations impede and R- binding and R- activity. This results in increased cell motility, invasion, adhesion, and lamellipodia extension.
control cell movement via their transmembrane receptors, the plexins. The scientists figured, that the pathway in control of cell migration could be used by cells for invasion and metastasis.

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