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Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

plays an important role in the immune system and could be used as a therapeutic target for autoimmune diseases, as Masataka Asagiri and his team from the Tokyo Medical and Dental University (Japan) report.

is known to be an osteoclast-specific lysosomal protease. An inhibitor of this protease was assumed to have a potential as therapeutic target.

The scientists showed in their study that inhibition of effectively suppressed autoimmune inflammation of the joints as well as osteoclastic bone resorption in autoimmune arthritis. -/- mice proved to be resistant against experimental autoimmune encephalomyelitis. Pharmacological inhibition or targeted disruption of led to defective signalling in in response to unmethylated CpG DNA. In turn, T helper 17 cells activation was diminished, but the antigen-presenting ability of the was not affected.

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