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Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T- Cell Development

Differentiation of class I-restricted changed into CD8- helper-like , when transcription factor complexes were absent. Usually, double-positive differentiate into helper-lineage cells when expressing the transcription factor , but without it they take the path of the cytotoxic lineage.

Within the locus there exists a -binding sequence which acts as transcriptional silencer, essential for the development of by blockade of .
It seems that expression and T-helper cell development are actively inhibited by -dependent silencing, permitting differentiation.

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