You are viewing an incomplete version of our website. Please click to reload the website as full version.
Areas: ,

Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes

Antigen presentation at the lymph node periphery has a prominent function for antiviral activation. Previously it was believed that antiviral activation would mainly occur at lymphocyte exit sites in deeper lymph node venules.

But scientists from the National Institute of Allergy and Infectious Diseases (USA) demonstrated by intravital microscopy how the activation takes place.

They analyzed mice infected with either (a large DNA virus) or (a small RNA virus). The virions drained to the lymph node and infected cells resided just beneath the subcapsular sinus. Naive rapidly migrated to infected cells in the peripheral interfollicular region to form tight interactions with which completed activation.

Related antibodies on antibodies-online.com:

Antibodies for the research area immunology:

Antibodies for the research area virology: