Application of antibodies to the N-terminus of amyloid prevented the LTP and LTD deficiencies. Antibodies directed against the midregion of the C-terminus were not as successful.

If instead of soluble amyloid, insoluble amyloid plaque cores were used, still taken from a Morbus Alzheimer cortex, LTP was not impaired. In case the plaques were solubised and thus released amyloid dimers, LTP was also effectively inhibited. The plaques, therefore, seem to be mostly inactive except for segregating synaptotoxic amyloid dimers.

The research group suggest that soluble amyloid oligomers that were extracted from Morbus Alzheimer brains can very effectively inhibit the structure and function of synapses. Amyloid dimers seem to be the smallest synaptotoxic unit.

Related antibodies on antibodies-online.com:

Amyloid-beta protein

Amyloid, N-terminal

Amyloid-beta, N-terminal

Amyloid-beta, C-terminal

Amyloids

Glutamate receptors

N-methyl D-aspartate receptors:
Glutamate Receptor, Ionotropic, N-methyl D-aspartate receptor 1
Glutamate Receptor, Ionotropic, N-methyl D-aspartate receptor 2b
Glutamate Receptor, Ionotropic, N-methyl D-aspartate receptor 2c
Glutamate Receptor, Ionotropic, N-methyl D-aspartate receptor 3a
Glutamate Receptor, Ionotropic, N-methyl D-aspartate receptor 3b

Metabotropic glutamate receptors:
Glutamate receptor, metabotropic 1
Glutamate receptor, metabotropic 2
Glutamate receptor, metabotropic 3
Glutamate receptor, metabotropic 6
Glutamate receptor, metabotropic 7
Glutamate receptor, metabotropic 8

Antibodies for the research area Morbus Alzheimer: »Show antibodies

Antibodies for the research area receptors: »Show antibodies