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Areas: ,

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

The () is selected for ubiquitination and subsequent degradation by binding to the tumour suppressor protein

loss and deletion or mutation of (), which also activates were reciprocally related in human breast cancer cell lines and primary tumours.
Tumour cell lines with deletions or mutations of inside their genome were observed to be especially sensitive to rapamycin treatment. The loss of could thus be used as a biomarker for human cancers that are treatable with pathway inhibitors.

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Antibodies for the research area enzymes:

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