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Allergic Airway Inflammation and Airway Hyperreactivity is Mediated by IL17 Producing gamma/delta T Cells

While the exact mechanisms are unknown, are postulated to exert a regulatory influence during acute allergic airway disease. Allergic airway disease has been attributed to producing Th17 cells. A recently published study in Respiratory and Critical Care Medicine has found that represent the main source of in the allergic lung. The study utilized a T-cell receptor antibody available at antibodies-online.

represent a small subset of T cells that possess a distinct T cell receptor (TCR) on their surface. They are also distinct in that they apparently do not require antigen processing and MHC presentation of peptide epitopes. Nevertheless, some gamma/delta T cells recognize MHC class IB molecules. This recent publication identifies these producing as key regulators of allergic response in vivo.