Area: Cardiovascular Matrix metalloproteinases reduce beta-2-adrenergic receptor density and cause spontaneous hypertension Enhanced matrix metalloproteinase (MMP) activity has been observed in spontaneously hypertensive rats (SHR). A recent study reports, that MMPs may contribute to the reduced density of the extracellular domain of beta-2-AR in blood vessels and to the increased arteriolar tone of SHRs compared with normotensive rats. The study utilized this anti-beta-2-AR antibody that recognizes the N-terminal region of the protein and can be used for ELISA and western blotting. The beta-2-adrenergic receptor (AR) is a member of the G protein-coupled receptor superfamily. Different polymorphic forms, point mutations, or alterations in the expression regulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. More »beta-2-adrenergic receptor (AR) antibodies The published study can be found here: Source: Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H25-35. Epub 2010 Apr 9. Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats. Rodrigues SF et. al.