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Matrix metalloproteinases reduce beta-2-adrenergic receptor density and cause spontaneous hypertension

Enhanced activity has been observed in spontaneously hypertensive rats (SHR). A recent study reports, that MMPs may contribute to the reduced density of the extracellular domain of beta-2-AR in blood vessels and to the increased arteriolar tone of SHRs compared with normotensive rats. The study utilized this anti-beta-2-AR antibody that recognizes the N-terminal region of the protein and can be used for ELISA and western blotting.

The is a member of the G protein-coupled receptor superfamily. Different polymorphic forms, point mutations, or alterations in the expression regulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

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The published study can be found here: