SARS-CoV-2 Spike Protein (B.1.617.1 - kappa) (rho-1D4 tag)
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- Key Features
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- Recombinant trimeric S protein of the SARS-CoV-2 variant of concern B.1.617.
- Contains E154K, L452R, E484Q, D614G, and P681R mutations characteristic for the SARS-CoV-2 kappa variant (B.1.617.1).
- Target See all SARS-CoV-2 Spike Proteins
- SARS-CoV-2 Spike
- Protein Type
- Recombinant
- Protein Characteristics
- B.1.617.1 - kappa
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Origin
- SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Kappa
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This SARS-CoV-2 Spike protein is labelled with rho-1D4 tag.
- Application
- ELISA, Ligand Binding Assay (LBA)
- Purpose
- This is the spike protein of the mutant strain B.1.617, also commonly known as the "India" or "Kappa mutant".
- Sequence
- 1286 amino acids (including Rho1D4 tag and linker)
- Specificity
- Mutation that differ from "original" SPIKE protein: G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H
- Characteristics
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"SARS CoV-2 full-length Spike B.1.617 Mutation"
All viruses undergo fast mutations and adept quickly to the countermeasures that the immune systems creates against them. SARS-CoV-2 of the COVID-19 pandemic is no exception here. During the pandemic multiple mutant strains arose. To help the science combat these mutants we offer these mutant SPIKE proteins.
We offer the SPIKE protein of the mutants in full-length and active in their native trimeric form, stabilized with the LMNG detergent. - Purity
- > 98% as determined by SDS-PAGE
- Top Product
- Discover our top product SARS-CoV-2 Spike Protein
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Further modifications:
- furin cleavage site "682-RRAR|SV-687" mutated to "682-GSAG|PP-687"
- C-terminal Rho1D4 tag fused with spacer "GSSG" to protein sequence
Size: 1286 amino acids (including Rho1D4 tag and linker) - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 20 mM Hepes pH 7.5, 150 mM NaCl, 0.001 % LMNG
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Avoid freeze-thaw cycles
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- Target
- SARS-CoV-2 Spike
- Alternative Name
- SARS2 Spike glycoprotein (SARS-CoV-2 Spike Products)
- Synonyms
- E2 Protein, E2 glycoprotein precursor Protein, Surface Glycoprotein Protein, S Protein
- Target Type
- Viral Protein
- Background
- All viruses undergo fast mutations and adapt quickly to the countermeasures that the immune systems creates. SARS-CoV-2 of the COVID-19 pandemic is no exception to this. During the pandemic multiple mutant strains arose.
- Molecular Weight
- 142190.43 Da
- UniProt
- P0DTC2
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