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Apoptosis

Apoptosis is a highly regulated process offering an organized way for an organism to dispose of cells that are no longer needed. It is initiated either through a specific class of death receptors or intrinsic factors such as DNA damage. Apoptosis is mainly driven by caspase proteases and further regulated by Bcl-2 and inhibitor proteins. Dysregulation of this programmed cell death is oftentimes associated with cancer.

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Autophagy

Autophagy is the regulated, self-degradative process of the cell that disassembles unnecessary or dysfunctional components. The lysosomal pathway is evolutionarily conserved and initiates engulfment, degradation and recycling of cellular contents including long-lived proteins and organelles thus promoting cell survival.

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Cell Division Cycle

Cell division unfolds in four stages - G1, S, G2, and M phase – depending on a number of internal or external signals. Progression through the different phases is driven by cyclin dependent kinases (CDK) and their activators, the cyclins. Additionally, their activity is further modulated by CDK inhibitors. Tight control of the cell cycle is essential to maintain proper cell homeostasis.

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Complement System

The complement system is part of the innate immune system and plays an important role in host defense, inflammation, tissue regeneration and other physiological processes. Depending on the invading pathogen it follows three established pathways: the classical, lectin, or alternative pathway.

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DNA Damage Repair

In any organism, various DNA repair mechanisms assure the integrity of the genetic information that is contained in the nucleus of every cell. The crucial significance of keeping the DNA intact is reflected by the number of different DNA repair pathways and the various proteins involved in these processes.

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Hedgehog Signaling

The Hedgehog (Hh) signaling cascade is one of the most important determinants for many developmental processes. Gene products of the targeted genes determine cellular stemness, renewal, survival, and migration. Deregulation of the Hh signal proteins and downstream effectors is pivotal during cancer progression.

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JAK-STAT Signaling

JAK-STAT signaling is highly conserved in vertebrates and even some other metazoans. The combination of receptor activated kinases and transcription factors make this signaling cascade one of the central cellular regulatory pathways.

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MAPK Signaling

Phosphorylation is the reversible process of attaching a phosphate group to a specific amino-acid residue on a protein. Functionally, phosphorylation acts as a simple molecular switch that can activate, deactivate, or modulate the function of a protein. Addition and removal of phosphate groups provide spatial and temporal control over protein activity.

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Microtubule Dynamics

Microtubules are highly-dynamic structural and functional intracellular highways. The term cytoskeleton conjures up an image of rigid, immutable, and permanent structure. In reality, the cytoskeleton is a highly dynamic interconnected network composed of three different principal components: microtubules ...

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NF-kappaB Signaling

NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) represent a group of homo- or heterodimeric transcription factors that are central in a network of various signal transduction pathways. A vast array of signals such as cytokines, growth factors and hormones, infections, oxidative stress,...

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Notch Signaling

The highly-conserved Notch signaling pathway is unique, as both the Notch receptor and most of its respective ligands...

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p53 Signaling

p53 is one of the most prominent tumor suppressors and is often called “the guardian of the genome”. Mutations of p53 or parts of its regulatory circuit are found in almost all cancers, which highlights its importance. It is conserving the stability of the genome by preventing mutations caused by cellular stress or DNA damage. p53 stabilizes the...

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PI3K-Akt Signaling

The PI3K/Akt pathway is pivotal for cellular homeostasis, neurological development, metabolism, and other processes. It regulates various aspects of cellular development such as apoptosis, cell cycle progression, and cell differentiation. The key regulator of the PI3K/Akt pathway is Akt/PKB, a family of three closely related serine/threonine-protein kinases...

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RTK Signaling

Receptor Tyrosine Kinases (RTKs) are membrane bound kinases that are activated upon binding of receptor specific ligands. They make up the largest class of membrane receptors that trigger signaling cascades through their inherent enzymatic activity.

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TLR Signaling

Toll-like receptors play an essential in the innate immune response against various pathogens such as viruses, bacteria, and fungi. TLRs elicit one of two conserved inflammatory pathways: either the TRIF- or the MyD88 dependent pathway. Besides, TLR signaling also induces dendritic cell maturation and the adaptive immune response.

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WNT Signaling

Wnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine...

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ACE Inhibitor Pathway

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Activated T Cell Proliferation

Browse our antibodies, ELISA kits and proteins related to activated T cell proliferation.

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Activation of Innate immune Response

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AMPK Signaling

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Asymmetric Protein Localization

Browse our antibodies, ELISA kits and proteins related to asymmetric protein localization.

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Brown Fat Cell Differentiation

Browse our antibodies, ELISA kits and proteins related to brown fat cell differentiation.

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C21-Steroid Hormone Metabolic Process

Browse our antibodies, ELISA kits and proteins related to C21-steroid hormone metabolic process.

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cAMP Metabolic Process

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Carbohydrate Homeostasis

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Caspase Cascade in Apoptosis

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Cell RedoxHomeostasis

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Cell-Cell Junction Organization

Browse our antibodies, ELISA kits and proteins related to cell-cell junction organization.

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Cellular Glucan Metabolic Process

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Cellular Response to Molecule of Bacterial Origin

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Chromatin Binding

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CXCR4-mediated Signaling Events

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Dicarboxylic Acid Transport

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DNA Replication

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Dopaminergic Neurogenesis

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EGFR Downregulation

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EGFR Signaling Pathway

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Embryonic Body Morphogenesis

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ER-Nucleus Signaling

Browse our antibodies, ELISA kits and proteins related to the ER-nucleus signaling pathway.

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Fc-epsilon Receptor Signaling Pathway

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Feeding Behaviour

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G-protein mediated Events

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Glycosaminoglycan Metabolic Process

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Growth Factor Binding

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Hepatitis C

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Hormone Activity

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Hormone Transport

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Inositol Metabolic Process

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Integrin Complex

Browse our antibodies, ELISA kits and proteins related to the integrin complex.

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Interaction of EGFR with phospholipase C-gamma

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Interferon-gamma Pathway

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Intracellular Steroid Hormone Receptor Signaling Pathway

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M Phase

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Maintenance of Protein Location

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Metabolism of Steroid Hormones and Vitamin D

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Methionine Biosynthetic Process

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Mitotic G1-G1/S Phases

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Monocarboxylic Acid Catabolic Process

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Myometrial Relaxation and Contraction

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Negative Regulation of Hormone Secretion

Browse our antibodies, ELISA kits and proteins related to negative regulation of hormone secretion.

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Negative Regulation of intrinsic apoptotic Signaling

Browse our antibodies, ELISA kits and proteins related to negative regulation of intrinsic apoptotic signaling.

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Negative Regulation of Transporter Activity

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Neurotrophin Signaling Pathway

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Nuclear Hormone Receptor Binding

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Nuclear Receptor Transcription Pathway

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Nucleotide Phosphorylation

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Peptide Hormone Metabolism

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Photoperiodism

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Phototransduction

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Platelet-derived growth Factor Receptor Signaling

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Positive Regulation of Endopeptidase Activity

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Positive Regulation of fat Cell Differentiation

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Positive Regulation of Immune Effector Process

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Positive Regulation of Peptide Hormone Secretion

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Positive Regulation of Response to DNA Damage Stimulus

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Production of Molecular Mediator of Immune Response

Browse our antibodies, ELISA kits and proteins related to the production of molecular mediator of immune response.

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Protein targeting to Nucleus

Browse our antibodies, ELISA kits and proteins related to the protein targeting to nucleus.

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Proton Transport

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Regulation of Actin Filament Polymerization

Browse our antibodies, ELISA kits and proteins related to the regulation of actin filament polymerization.

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Regulation of Carbohydrate Metabolic Process

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Regulation of Cell Size

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Regulation of G-Protein Coupled Receptor Protein Signaling

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Regulation of Hormone Biosynthetic Process

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Regulation of Hormone Metabolic Process

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Regulation of Intracellular Steroid Hormone Receptor Signaling

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Regulation of Leukocyte Mediated Immunity

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Regulation of Lipid Metabolism by PPARalpha

Browse our antibodies, ELISA kits and proteins related to the Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

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Regulation of long-term Neuronal Synaptic Plasticity

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Regulation of Muscle Cell Differentiation

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Regulation of Systemic Arterial Blood Pressure by Hormones

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Regulatory RNA Pathways

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Response to Growth Hormone Stimulus

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Response to Water Deprivation

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Retinoic Acid Receptor Signaling Pathway

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Ribonucleoprotein Complex Subunit Organization

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Ribonucleoside Biosynthetic Process

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Ribosome Assembly

Browse our antibodies, ELISA kits and proteins related to ribosome assembly.

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Sensory Perception of Sound

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Signaling Events mediated by VEGFR1 and VEGFR2

Browse our antibodies, ELISA kits and proteins related to signaling events mediated by VEGFR1 and VEGFR2.

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Signaling of Hepatocyte Growth Factor Receptor

Browse our antibodies, ELISA kits and proteins related to signaling of Hepatocyte Growth Factor receptor.

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Skeletal Muscle Fiber Development

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Smooth Muscle Cell Migration

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Stem Cell Maintenance

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Steroid Hormone Biosynthesis

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Steroid Hormone Mediated Signaling Pathway

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Synaptic Membrane

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Synaptic Vesicle Exocytosis

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Synthesis of DNA

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TCR Signaling

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Telomere Maintenance

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Thromboxane A2 Receptor Signaling

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Thyroid Hormone Synthesis

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Toll-Like Receptors Cascades

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Transition Metal Ion Homeostasis

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Tube Formation

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VEGFR1 Specific Signals

Browse our antibodies, ELISA kits and proteins related to VEGFR1 specific signals.

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