The transmembrane receptor TRAIL-R1 is a member of the TNF family and is being expressed in most human tissues. TRAIL-R1 has also been denominated death receptor (DR) 4 which derives from the pro-apoptotic action TRAIL-R1exhibits.
Apoptosis is activated by the ligand TRAIL and TRAIL-R1 has been shown to interact with the Death Associated Protein 3 (DAP3). Additionally, FAS-Associated Protein with Death Domain (FADD) mediated apoptosis has been shown to be mediated via TRAIL-R1 based signal transduction. Discover all TRAIL-R1 antibodies and their different capabilities in flow cytometry, immunoprecipitation, immunocytochemistry and functional applications
Source: Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36.