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Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

signalling seems to connect phagocytosis and autophagy, two ancient and during evolution highly conserved processes of organism defence against pathogens. In a recent study, Miguel A. Sanjuan and colleagues from the St Jude Children's Research Institute in Memphis (USA) report that a particle that recruits on murine on phagocytosis causes the autophagosome marker to rapidly accumulate in the phagosome. This process is dependent on the autophagy proteins and ATG7. activity and gathering of could be observed.

Autophagy is characterised by the generation of a double-layer membrane, the autophagosome. Fusion with lysosomes enables the autophagosome to destroy its content. This process shares similarities with phagosome maturation. The scientists now translocated and to the phagosome. The proteins were not involved in the formation of the characteristic double-membrane structures associated with autophagosomes, but they apparently were required for phagosome fusion with lysosomes, leading to a fast acidification and enhanced degeneration of the absorbed organisms.

activate multiple defence mechanisms within phagocytes, e.g. facilitation of phagosome maturation and autophagy. The scientists therefore consider signalling as a link between both processes, thereby improving the function of common phagosomes.

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