Studying the effect of Cox-2 inhibitors on upper gastrointestinal events

Conventional anti-inflammation drugs wich are not based on steroids heavily increase the risk of upper gastrointestinal events (e.g. bleeding ulcers). In order to decrease this risk selective inhibitors are used - among other measures.

It has been shown that the number of upper gastrointestinal events is significantly lower if selective inhibitors are employed compared to traditional non-steroidal anti-inflammatory drugs (NSAIDs). But these findings have not been based on real-world simulations. Loren Laine and her colleagues from the MEDAL Steering Committe address this shortcoming with their study. The results indicate that COX-2 selective inhibitors lower the overall risk of upper gastroinstetinal incidents. This finding is mainly due to the lower number of minor ulcers. No significant difference was detected for the more serious events. The authors also studied the effect of proton pump inhibitors and strongly encourage the use of these inhibitors.

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