Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress

The winged helix transcription factor is required for normal bile acid homeostasis, as a study conducted by Irina M. Bochkis and colleagues from the University of Pennsylvania (USA). The bile production in the liver is essential for the absorption of lipophilic nutrients. If the bile acid homeostasis is disrupted, cholestatic liver disease and endoplasmic reticulum (ER) stress can be the results.

Deletion of in murine via the Cre-lox system results in the decreased transcription of genes responsible for bile acid transporters on the basolateral and canalicular membranes. Intrahepatic cholestasis was the consequence. -deficient mice react sensitively to cholic acid in their food, which accumulates toxic levels of hepatic bile salts and leads to ER stress and liver injury.

The scientists also show decreased expression in liver samples from patients suffering from different cholestatic syndromes. It is therefore likely that a reduced amount of would negatively influence the severity of the injury.

Related antibodies on

Liver Antigen (Bile canaliculi)

Antibodies for the research area transcription factors: