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Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors

The intracellular pathogens and Coxiella burnetii use a type IV secretion system to deliver a large number of different proteins with Anks () into eukaryotic cells.

The advantage of microbial proteins that work inside a host cell is that they can imitate or disrupt eukaryotic factors. Thus, many use specialised secretion systems to get their proteins inside the eukaryotic cell.

The AnkX protein was observed to prevent microtubule-dependent vesicular transport. This disturbed the fusion of -containing vacuoles with late after of .
Ank proteins therefore must have effector functions that are important for of eukaryotic host cells.

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