Area: Cytoskeleton Protein crystal structure helps solving the role of ARL6 in Bardet-Biedl Syndrome ARL6 belongs to the ARF family of GTP-binding proteins. Many members of the large family of GTPases are known to play essential roles in modulating membrane trafficking and cytoskeletal functions. A new study presented the crystal structure of ARL6 and thereby helped to determine a mechanistic explanation for such pathogenic alterations like Bardet-Biedl syndrome. The study was performed using an ARL6 antibody available on antibodies-online. On antibodies-online you may find a list of ARL6 antibodies The full study is available here Source: J Biol Chem. 2010 May 21;285(21):16218-30. Epub 2010 Mar 5. Bardet-Biedl syndrome-associated small GTPase ARL6 (BBS3) functions at or near the ciliary gate and modulates Wnt signaling. Wiens CJ et. al.